Análise da expressão de interleucina-6 (IL6), fator de necrose tumoral alfa (TNF-alfa) e Sirtuina 1(SIRT 1) no tecido adiposo branco, tecido adiposo marrom e tecido hepático de indivíduos clinicamente saudáveis, caquéticos sacopênicos e obesos mórbidos

Abstract

Obesity leads to disturbances of the health conditions of the organism and these changes can be represented by psychological disorders, social and increased risk of morbidity and mortality from major diseases. With the increase in adipose tissue, and macrophage infiltration in this tissue, numerous pro - inflammatory cytokines, including tumor necrosis factor - alfa (TNF alfa) and interleukin - 6 (IL - 6) are concomitantly leading to an increased inflammatory state and a condition of chronic insulin resistance, which in turn induces a subsequent increase in circulating cytokines and fatty acids causing a state of lipotoxicity. In the first study is a comparison of the molecular expression of these cytokines in visceral adipose tissue of morbid obese patients, cachectic and normal. The second study is a comparative analysis of IL-6 expression in white adipose tissue and brown adipose tissue of morbid obese patients and their interactions with the metabolic profile, lipid and inflammatory these patients. The third article evaluated the association and corelação the expression of these cytokines with the severity of nonalcoholic fatty liver disease (NAFLD) in morbid obese patients. Our results establish that in morbidly obese patients have higher expression of cytokines TNF alpha and IL6 in abdominal fat compared to the group of adults of normal weight and obese patients IL6 expression in brown and white adipose tissue have different repercussions on human metabolism. We also observed that the quantitative expression of these cytokines was associated with BMI and that most TNF alpha expression was associated with greater severity of NAFLD. We conclude that morbid obese patients had an expression of these cytokines is associated directly and indirectly with the modulation of chronic inflammatory process described in the pathophysiology of obesity and its comorbidities, and the histological type of adipose tissue had different influences on the expression and IL-6 action in patients obese.