Análise da força muscular, fatores antropométricos, demográficos e biomarcadores plasmáticos em indivíduos adultos assintomáticos e portadores de doença renal crônica

Abstract

The present study aimed to investigate a series of socio-demographic, anthropometric, nutritional, biochemical (plasma), and handgrip strength factors between clinically healthy adults (controls) and patients with chronic kidney disease (CKD) in order to better understand CKD-related cachexia. The first study evaluated the actual effects of physical activity or exercise on the physical wasting related to CKD). To do this a systematic review of the literature was carried out, selecting international scientific articles published in English, found on electronic search sites for scientific articles and journals: Lilacs, Scielo, Medline, Science Direct, Google Academic e PubMed. The originally selected articles (n=416), from 2004-2015, allowed for the delimitation of 9 studies with random clinical experimental designs. According to these studies, both physical exercise and physical activity represent promising non-pharmaceutical therapies that promote the gain of weight and muscular force, resulting in a better quality of life for patients. In the second transversal-analytical study, there was an evaluation of possible associations between socio-demographic variables, anthropometric data, clinical data (physical and nutritional data), serum biochemistry and the strength of handgrip in clinically healthy adults (n=230; male/female ratio = 1:1.6; age = 55.65 years ± 11.26). Our results show that handgrip force was found to be associated with different factors in accordance with the sex of the individuals. In men, handgrip force was associated with serum eosinophil and glycemic counts. In women, handgrip force was associated with height and glycemic counts. The third case control study, we compared a series of demographic, anthropometric, clinical (physical and nutrition exams), serum biochemistry and strength of handgrip factors between clinically healthy individuals (controls, n=156) and patients with CKD (n=116). Our findings show that individuals with CKD present with less handgrip strength, Body Mass Index (BMI), lean mass and lower serum levels of hemoglobin and platelets, compared to individuals in the control group. Furthermore, the presented with higher serum levels of C-reactive proteins, neutrophils and percent of body water.