Efeito citotóxico e genotóxico de extratos Stryphnodendron polyphyllum Mart. e ação larvicida sobre Aedes aegypti

Abstract

Plant-derived larvicides have been indicated as low-cost biodegradable strategies for the control of the Aedes aegypti mosquito, dengue transmitter, zika, chikungunya and yellow fever, this work aimed to evaluate the effect of aqueous, ethanolic and hydroalcoholic extracts produced to from Barbatimão (Stryphnodendron Polyphyllum Mart.) As an alternative method in controlling Aedes aegypti larvae as well as cytotoxic and genotoxic potential. Plant material was collected from different trees in the city of Bocaiúva-MG and the statements to be evaluated were produced at concentrations of 100, 75, 50, 25, 12.5% for aqueous extracts and 7200, 3600, 1800, 900 , 700, 600, 400 and 200 ppm for ethanolic and hydroalcoholic extracts. To evaluate toxicity against non-target organisms, tests with Artemia salina and Allium cepa was used. Preliminary phytochemical tests were performed for the characterization of leaf metabolites. It was observed that the aqueous extract produced through the leaves of S. polyphyllum obtained 100% mortality of A. aegypti larvae after 48 hours of exposure. Toxicity was not observed against A.Salina and Allium cepa tests showed interference in the mitotic process attesting cytotoxicity, but genotoxic action was not observed. Thus, the larvicidal activity of the leaf aqueous extract of S. polyphyllum against the Aedes aegypti larvae and cytotoxic activity of extracts.