Avaliação do extrato da casca do fruto do pequizeiro (Caryocar brasiliense camb.) como componente ativo principal na formulação de fotoprotetores

Abstract

In Brazil, non-melanoma skin cancer is the most frequent and corresponds to about 30% of all malignant tumors registered in the country. Several factors are related to the development of skin diseases such as habits and customs, quality of life, genetic factors and exposure to solar radiation. The use of sunscreens is the main alternative for reducing the effects of radiation on the skin and preventing associated diseases. Many studies have been carried out with the aim of developing sunscreens that contain natural products in the disposal. In this study, in order to evaluate the possibility of using the peel extract of the pequi fruit (Caryocar brasiliense Camb.) in the composition of photoprotective formulations, tests were carried out to evaluate the photoprotective and antioxidant capacity of the extract and formulations where the extract was used as active main ingredient. Preliminary stability tests of the formulations were also carried out to guarantee their safety and quality. The photoprotective capacity was evaluated in vitro by the sun protection factor and the antioxidant activity was evaluated by the reduction capacity of the diphenyl picryl hydrazine radical. Preliminary stability of the formulations was evaluated by the centrifugation resistance test, the thermal stress test and the stability test at high and low temperatures. The ethanol extract has photoprotective capacity and antioxidant activity proportional to the concentration of the extract. Formulations containing the extract in smaller minors (FPS 15) dissipate more effectively and stable. It is concluded that the ethanol extract of the pequi fruit peel has photoprotection characteristics and antioxidant activity and that the use of this extract as an active ingredient in formulations confers efficacy on photoprotection, however, characteristics desired for a photoprotective source.