Atividade antimicrobiana dos extratos de Pera glabrata (Euphorbiaceae) (Schott) Poepp. ex Baill em bactérias e leveduras patogênicas

Abstract

In this study, Pera glabrata was analyzed as a possible holder of bioactive molecules able to carry out antimicrobial activity. This plant has a wide distribution, coming from the south of Brazil to the north of Venezuela. Without reports for medical use this is only popularly used for shoe manufacturing. The antimicrobial activity was evaluated against standard strains of Candida albicans, Candida krusei, Candida tropicalis, Pseudomonas aeruginosa, Escherichia coli, Proteus mirabilis, Salmonella by microdilution in broth. Determination of the inhibitory process was by reading absorbance, by staining with risazurin and by counting in plates. The butanol extracts presented good inhibitory or partial inhibition capacity, especially the cold butanolic extract, which obtained better results for six bacteria in the MIC test. The other extracts presented good results in preliminary tests, but were not successful in the tests for minimum inhibitory concentration. Interesting results were observed for the Candida strains, with partial inhibition for preliminary tests. Due to the observed activities, P. glabrata deserves attention, since these results are promising for a possible source of bioactive molecules.