Associação de fatores clínicos, antropométricos, nutricionais e expressão plasmática de proteína-C reativa e albumina com a ocorrência de Caquexia em indivíduos com Carcinoma de células escamosas de cabeça e pescoço

Abstract

Individuals with head and neck squamous cell carcinoma (HNSCC) often develop Cachexia related cancer (CRC) due to voluntary loss of muscle mass, allied or not with fat mass. Nutritional support does not unable to reverse the quality of the condition, influencing life, nutritional and physical status, consequently, the efficiency of anticancer therapies. The difficult access to complex imaging exams is a challenge for early diagnosis, simple methods which make use of great relevance for the planning of multimodal treatment, with an impact on the reduction of the higher inside of the morbidity and mortality characteristic of HNSCC. The study aimed to analyze the association between anthropomorphic, clinical, and statistical parameters and C-reactive protein (CRP) and albumin with the occurrence of CRC in individuals with HNSCC. The study was longitudinal, prospective, approved, and analytical. It was evaluate 125 patients in Montes Claros-MG, from 2019 to 2022. The grouping of individuals accordingly of staging of CRC, namely: non-cachectic, pre-cachectic, or cachectic. Interviews and consultations of medical records checked demographic and clinical data. At the physical examination, handgrip strength, gait speed, and anthropometric measurements going measured. Serum levels of CRP and albumin were quantification of blood samples performed using the enzyme immunoassay technique. A descriptive analysis characterized the example and bivariate statistical tests and applied them to study variables. A level significance of 5% with a CI of 95% considered. This study going approved by the ethics committee in human research (CEP/Unimontes; opinion nº: 3217306; CAAE 09006719100005146). In the multiple analyses, going identified that: age, functional performance, CRP/albumin ratio, arm muscle circumference (MAMC) and arm fat percentage (AFI) are predictors for CRC in individuals with HNSCC. Patients older than 60 years (OR=3.88, 95%CI=1.16-12.95), with functional performance ≤90% (OR=5.51, 95%CI=1.41- 21.45) and increased CRP/albumin ratio (OR=1.47, 95CI %=1.10-1.97) are more likely to develop CRC. The increase in MAMC (OR=0.65, CI95%=0.52-0.82) and AFI (OR=0.91, CI95%=0.84-0.98) is associated with a lower chance of CRC. The study points out that instituting healthy habits and physical activities in individuals with HNSCC during their process elderly may be protective factors in the development of cachexia associated with cancer.