Potencial antineoplásico do ácido gálico em camundongos submetidos à exposição ao carcinógeno 4NQO e da nanopartícula AICIPc em células Scc9: duas novas propostas.

Abstract

Oral cancer causes significant morbidity and mortality. Around the world, squamous cell carcinoma (OSCC) is the sixth most common cancer. Treatment modalities are available in surgery, radiotherapy, chemotherapy and prevention strategies, including lifestyle changes as well as chemoprevention. Photodynamic Therapy (PDT), due to the death of neoplastic cells, has been the target of photosensitization and light in the proper wave direction. It has been an alternative to chemotherapy and radiotherapy for the clinical treatment of cancer makes the treatment less aggressive for the patient. This work presented the new measures for the treatment of OSCC: a photosensitizer (AlClPc) as once existing, of reduced sessions and the Gallic Acid, which by its own antioxidants and anti-inflammatory effects has a more effective antineoplastic action, the which makes it a promising agent in the treatment of OSCC. PDT was performed in vitro on Scc9 cells in which assays were performed to evaluate the cellular phenotype after treatment with AlClPc. Gallic acid was administered gavage in animals after treatment with the carcinogen 4nqo. The animals were weighed daily for GA oral dosing until the animals died. A PDT caused cell death (p <0.05) and Gallic acid attenuated lesions in the animals' tongues. The results of this work may be the starting point for new alternatives for the treatment of oral cancer.